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Altered carbohydrate, lipid, and xenobiotic metabolism by liver from rats flown on Cosmos 1887To determine the possible biochemical effects of prolonged weightlessness on liver function, samples of liver from rats that had flown aboard Cosmos 1887 were analyzed for protein, glycogen, and lipids as well as the activities of a number of key enzymes involved in metabolism of these compounds and xenobiotics. Among the parameters measured, the major differences were elevations in the glycogen content and hydroxymethylglutaryl-CoA (HMG-CoA) reductase activities for the rats flown on Cosmos 1887 and decreases in the amount of microsomal cytochrome P-450 and the activities of aniline hydroxylase and ethylmorphine N-demethylase, cytochrome P-450-dependent enzymes. These results support the earlier finding of differences in these parameters and suggest that altered hepatic function could be important during spaceflight and/or the postflight recovery period.
Document ID
Document Type
Reprint (Version printed in journal)
Merrill, A. H. Jr
(Emory University School of Medicine Atlanta, Georgia 30322)
Hoel, M.
Wang, E.
Mullins, R. E.
Hargrove, J. L.
Jones, D. P.
Popova, I. A.
Merrill AH, J. r.
Date Acquired
August 22, 2013
Publication Date
January 1, 1990
Publication Information
Publication: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Volume: 4
Issue: 1
ISSN: 0892-6638
Subject Category
Life Sciences (General)
Distribution Limits
NASA Experiment Number COS 1887-4
Non-NASA Center
Flight Experiment
NASA Discipline Regulatory Physiology
short duration
Cosmos 1887 Project
NASA Discipline Number 00-00
NASA Program Flight
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