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Conformation-dependent recognition of a protein by T-lymphocytes: apomyoglobin-specific T-cell clone recognizes conformational changes between apomyoglobin and myoglobinA T-cell clone specific to apomyoglobin was generated. It was prepared from a T-cell culture obtained by in vitro driving of lymph node cells with apomyoglobin from SJL mice that have been primed in vivo with apomyoglobin. In proliferative assays, the T-cell clone responded to apomyoglobin but did not recognize native myoglobin or any of the synthetic peptides corresponding to the six T sites of myoglobin. The demonstration that a T-cell clone can be isolated, whose specificity is directed entirely to apomyoglobin and not to its counterpart myoglobin, with an identical amino acid composition, indicates the importance of the three-dimensional structure in the presentation of the protein to T cells.
Document ID
20050036243
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Cohly, H. H.
(NASA Johnson Space Center Houston, TX United States)
Morrison, D. R.
Atassi, M. Z.
Date Acquired
August 22, 2013
Publication Date
June 1, 1988
Publication Information
Publication: Immunological investigations
Volume: 17
Issue: 4
ISSN: 0882-0139
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other

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