NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
The Hindlimb Unloading Rat Model: Literature Overview, Comparison with Spaceflight Data, and Technique UpdateThe hindlimb unloading (HU) rodent model is used extensively to study the response of many physiological systems to certain aspects of spaceflight, as well as to disuse and recovery from disuse for Earth benefits. This chapter describes the evolution of HU, and is divided into three sections. The first section examines the characteristics of 1063 articles using or reviewing the HU model, published between 1976 and April 1, 2004. The characteristics include number of publications, journals, countries, major physiological systems, method modifications, species, gender, genetic strains and ages of rodents, experiment duration, and countermeasures. The second section provides a comparison of results between space flown and Hu animals from the 14-day Cosmos 2044 mission. The final section describes modifications to HU required by different experimental paradigms and a method to protect the tail harness for long duration studies. HU in rodents has enabled improved understanding of the responses of the musculoskeletal, cardiovascular, immune, renal, neural, metabolic, and reproductive systems to unloading and/or to reloading on Earth with implications for both long-duration human spaceflight and disuse on Earth.
Document ID
20050156639
Acquisition Source
Ames Research Center
Document Type
Book
Authors
Morey-Holton, Emily
(NASA Ames Research Center Moffett Field, CA, United States)
Globus, Ruth K.
(NASA Ames Research Center Moffett Field, CA, United States)
Kaplansky, Alexander
(NASA Ames Research Center Moffett Field, CA, United States)
Durnova, Galina
(NASA Ames Research Center Moffett Field, CA, United States)
Date Acquired
August 23, 2013
Publication Date
July 16, 2004
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

Available Downloads

There are no available downloads for this record.
No Preview Available