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Record Details

Record 32 of 862
The Fractal-based Analysis of the Regulation of Vascular Remodeling in the Quail Chorioallantoic Membrane
Author and Affiliation:
Smith, Genee S.(Fayetteville State Univ., Biology, NC, United States)
Abstract: Critical to the advancement of space exploration is the safety and well being of astronauts while in space. This study focuses on the second highest of NASA-defined risk categories for human space exploration, cardiovascular alterations. Current research of this problem is being tackled by investigating angiogenesis through vascular remodeling. Angiogenesis is the growth and formation of new blood vessels. Angiogenesis is an important part of maintaining normal development and bodily functions. The loss of control of this process, either insufficient or excessive vascular growth, is considered a common denominator in many diseases, such as cancer, diabetes, and coronary artery disease. Objectives are presently being met by observing the effects of various regulators, like thrombospondin 1 (TSP-1) and a novel vessel tortuosity factor (TF), through the use of the chorioallantoic membrane (CAM) of Japanese quail embryos, which enables the direct optical imaging of 2-dimensional vascular branching trees. Research within the CAM is being performed to deduce numerous methods of regulating vessel growth. This project centers on the ability of a novel vessel regulator to affect angiogenesis. For example, it is hypothesized that the TSP-1 will inhibit the growth of CAM vasculature. Fractal/VESGEN-based techniques and PTV analysis are the methodologies used to investigate vascular differentiation. This tactic is used to quantify results and measure the growth patterns and morphology of blood vessels. The regulatory mechanisms posed by this vessel regulator can be deduced by alterations found within the vasculature patterns of quail embryos.
Publication Date: Jan 01, 2004
Document ID:
20050186870
(Acquired Jul 14, 2005)
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Conference Paper
Publication Information: Research Symposium I; (SEE 20050186794)
Meeting Sponsor: NASA Glenn Research Center; Cleveland, OH, United States
Financial Sponsor: Fayetteville State Univ.; Biology; NC, United States
Organization Source: Fayetteville State Univ.; Biology; NC, United States
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: No Copyright
NASA Terms: CARDIOVASCULAR SYSTEM; FRACTALS; MEMBRANES; BIRDS; EMBRYOS; METABOLIC DISEASES; BLOOD VESSELS; SPACE EXPLORATION; CORONARY ARTERY DISEASE; RISK
Availability Notes: Abstract Only; Available from STI Support Services only as part of the entire parent document
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