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Record 2 of 160
Radiation-induced bystander effect and adaptive response in mammalian cells
Author and Affiliation:
Zhou, H.(College of Physicians and Surgeons, Columbia University, Center for Radiological Research, New York, NY 10032, United States)
Randers-Pehrson, G.
Waldren, C. A.
Hei, T. K.
Abstract: Two conflicting phenomena, bystander effect and adaptive response, are important in determining the biological responses at low doses of radiation and have the potential to impact the shape of the dose-response relationship. Using the Columbia University charged-particle microbeam and the highly sensitive AL cell mutagenic assay, we show here that non-irradiated cells acquire mutagenesis through direct contact with cells whose nuclei have been traversed with a single alpha particle each. Pretreatment of cells with a low dose of X-rays four hours before alpha particle irradiation significantly decreased this bystander mutagenic response. Results from the present study address some of the fundamental issues regarding both the actual target and radiation dose effect and can contribute to our current understanding in radiation risk assessment. c2004 COSPAR. Published by Elsevier Ltd. All rights reserved.
Publication Date: Jan 01, 2004
Document ID:
20050193741
(Acquired Aug 02, 2005)
Subject Category: AEROSPACE MEDICINE
Document Type: Journal Article
Publication Information: Advances in space research : the official journal of the Committee on Space Research (COSPAR); p. 1368-72; Volume 34; 6
Publisher Information: United States
Contract/Grant/Task Num: CA 49062; RR 11623
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: ADAPTATION; ALPHA PARTICLES; CELLS (BIOLOGY); MAMMALS; MUTAGENESIS; RADIATION EFFECTS; ANTIGENS; CHROMOSOMES; CULTURED CELLS; FREE RADICALS; GENE EXPRESSION REGULATION; HAMSTERS; PARTICLE ACCELERATORS; RADIATION DOSAGE; RADIATION TOLERANCE; RISK
Other Descriptors: ADAPTATION, PHYSIOLOGICAL/PHYSIOLOGY/RADIATION EFFECTS; ALPHA PARTICLES; BYSTANDER EFFECT/RADIATION EFFECTS; HYBRID CELLS/DRUG EFFECTS/PHYSIOLOGY/RADIATION EFFECTS; MUTAGENESIS/PHYSIOLOGY/RADIATION EFFECTS; ACETYLCYSTEINE/PHARMACOLOGY; ANIMALS; ANTIGENS, CD59/RADIATION EFFECTS; CELL LINE; CHROMOSOMES, HUMAN, PAIR 11/RADIATION EFFECTS; DOSE-RESPONSE RELATIONSHIP, RADIATION; FREE RADICAL SCAVENGERS/PHARMACOLOGY; GENE EXPRESSION REGULATION/RADIATION EFFECTS; HAMSTERS; HUMANS; OCTANOLS/PHARMACOLOGY; PARTICLE ACCELERATORS; RADIATION TOLERANCE/RADIATION EFFECTS; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S; RESEARCH SUPPORT, U.S. GOV'T, P.H.S; RISK ASSESSMENT/METHODS; X-RAY THERAPY; NASA DISCIPLINE RADIATION HEALTH; NON-NASA CENTER
Availability Source: Other Sources
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