NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Incidence of associated events during the performance of invasive procedures in healthy human volunteersMetabolic investigations often utilize arteriovenous sampling and muscle biopsy. These investigations represent some risk to the subject. We examined 369 studies performed in the General Clinical Research Center between January 1994 and May 2003 for events related to femoral catheterization and muscle biopsies. Incidents were further examined by age (younger: 18-59 yr, n=133; and older: 60-76 yr, n=28). There were no clinically defined major complications associated with either procedure. The incidence of femoral catheter repositioning or reinsertion was higher in the older group (25.5 vs. 9.7%). There was no difference in the incidence of premature removal of catheters, ecchymosis or hematoma, or the persistence of pain after discharge. The occurrence of all incidents did not increase with multiple catheterizations. Muscle biopsy was associated with infrequent ecchymosis or hematoma in both groups (1.1 and 3.6% in younger and older groups, respectively). Both procedures entail a small likelihood of a vagallike response (3.3% overall), resulting in nausea, dizziness, and rarely a loss of consciousness. These results indicate that, in skilled hands and a defined clinical setting, the incidents associated with femoral catheterization and muscle biopsy in healthy volunteers are reasonable and largely controllable.
Document ID
20050194470
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Highstead, R. Grant
(Shriners Hospitals for Children 815 Market St. Galveston, TX 77550, United States)
Tipton, Kevin D.
Creson, Daniel L.
Wolfe, Robert R.
Ferrando, Arny A.
Date Acquired
August 23, 2013
Publication Date
April 1, 2005
Publication Information
Publication: Journal of applied physiology (Bethesda, Md. : 1985)
Volume: 98
Issue: 4
ISSN: 8750-7587
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: AG 15780
CONTRACT_GRANT: AG 17231
CONTRACT_GRANT: AR-49038
CONTRACT_GRANT: DK-38010
CONTRACT_GRANT: DK-33952
CONTRACT_GRANT: DK-46017
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Musculoskeletal
Non-NASA Center
Clinical Trial

Available Downloads

There are no available downloads for this record.
No Preview Available