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Record Details

Record 8 of 1514
Extracting trends from two decades of microgravity macromolecular crystallization history
External Online Source: doi:10.1107/S0907444904028902
Author and Affiliation:
Judge, Russell A.(NASA Marshall Space Flight Center, Huntsville, AL United States)
Snell, Edward H.
van der Woerd, Mark J.
Abstract: Since the 1980s hundreds of macromolecular crystal growth experiments have been performed in the reduced acceleration environment of an orbiting spacecraft. Significant enhancements in structural knowledge have resulted from X-ray diffraction of the crystals grown. Similarly, many samples have shown no improvement or degradation in comparison to those grown on the ground. A complex series of interrelated factors affect these experiments and by building a comprehensive archive of the results it was aimed to identify factors that result in success and those that result in failure. Specifically, it was found that dedicated microgravity missions increase the chance of success when compared with those where crystallization took place as a parasitic aspect of the mission. It was also found that the chance of success could not be predicted based on any discernible property of the macromolecule available to us.
Publication Date: Jun 01, 2005
Document ID:
20050206732
(Acquired Sep 01, 2005)
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: Acta crystallographica. Section D, Biological crystallography (ISSN 0907-4449); Volume 61; Pt 6; 763-71
Publisher Information: Denmark
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: CRYSTALLIZATION; CRYSTALLOGRAPHY; MICROGRAVITY; TRENDS; WEIGHTLESSNESS; X RAY DIFFRACTION; HISTORIES
Other Descriptors: CRYSTALLOGRAPHY, X-RAY/HISTORY/METHODS; WEIGHTLESSNESS; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S; REVIEW; REVIEW, TUTORIAL
Availability Source: Other Sources
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