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Mouse infection models for space flight immunologySeveral immunological processes can be affected by space flight. However, there is little evidence to suggest that flight-induced immunological deficits lead to illness. Therefore, one of our goals has been to define models to examine host resistance during space flight. Our working hypothesis is that space flight crews will come from a heterogeneous population; the immune response gene make-up will be quite varied. It is unknown how much the immune response gene variation contributes to the potential threat from infectious organisms, allergic responses or other long term health problems (e.g. cancer). This article details recent efforts of the Kansas State University gravitational immunology group to assess how population heterogeneity impacts host health, either in laboratory experimental situations and/or using the skeletal unloading model of space-flight stress. This paper details our use of several mouse strains with several different genotypes. In particular, mice with varying MHCII allotypes and mice on the C57BL background with different genetic defects have been particularly useful tools with which to study infections by Staphylococcus aureus, Salmonella typhimurium, Pasteurella pneumotropica and Ehrlichia chaffeensis. We propose that some of these experimental challenge models will be useful to assess the effects of space flight on host resistance to infection.
Document ID
20050218295
Document Type
Reprint (Version printed in journal)
Authors
Chapes, Stephen Keith (Kansas State University Manhattan, KS 66506, United States)
Ganta, Roman Reddy
Chapers, S. K.
Date Acquired
August 23, 2013
Publication Date
January 1, 2005
Publication Information
Publication: Advances in space biology and medicine
Volume: 10
ISSN: 1569-2574
Subject Category
Aerospace Medicine
Funding Number(s)
CONTRACT_GRANT: AI052206
CONTRACT_GRANT: AI55052
CONTRACT_GRANT: NAG2-1197
CONTRACT_GRANT: NCC5-168
CONTRACT_GRANT: NAG2-1274
CONTRACT_GRANT: AI50785
Distribution Limits
Public
Copyright
Other
Keywords
Review
NASA Discipline Regulatory Physiology
Review, Tutorial
Non-NASA Center