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The hindlimb unloading rat model: literature overview, technique update and comparison with space flight dataThe hindlimb unloading rodent model is used extensively to study the response of many physiological systems to certain aspects of space flight, as well as to disuse and recovery from disuse for Earth benefits. This chapter describes the evolution of hindlimb unloading, and is divided into three sections. The first section examines the characteristics of 1064 articles using or reviewing the hindlimb unloading model, published between 1976 and April 1, 2004. The characteristics include number of publications, journals, countries, major physiological systems, method modifications, species, gender, genetic strains and ages of rodents, experiment duration, and countermeasures. The second section provides a comparison of results between space flown and hindlimb unloading animals from the 14-day Cosmos 2044 mission. The final section describes modifications to hindlimb unloading required by different experimental paradigms and a method to protect the tail harness for long duration studies. Hindlimb unloading in rodents has enabled improved understanding of the responses of the musculoskeletal, cardiovascular, immune, renal, neural, metabolic, and reproductive systems to unloading and/or to reloading on Earth with implications for both long-duration human space flight and disuse on Earth.
Document ID
20050218297
Acquisition Source
Ames Research Center
Document Type
Reprint (Version printed in journal)
Authors
Morey-Holton, Emily
(NASA Ames Research Center Moffett Field, CA United States)
Globus, Ruth K.
Kaplansky, Alexander
Durnova, Galina
Date Acquired
August 23, 2013
Publication Date
January 1, 2005
Publication Information
Publication: Advances in space biology and medicine
Volume: 10
ISSN: 1569-2574
Subject Category
Aerospace Medicine
Distribution Limits
Public
Copyright
Other
Keywords
Flight Experiment
Cosmos 2044 Project
NASA Discipline Musculoskeletal
short duration
NASA Center ARC
Review
unmanned
Review, Tutorial

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