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Effects of heavy ion to the primary culture of mouse brain cellsTo investigate effects of low dose heavy particle radiation to CNS system, we adopted mouse neonatal brain cells in culture being exposed to heavy ions by HIMAC at NIRS and NSRL at BNL. The applied dose varied from 0.05 Gy up to 2.0 Gy. The subsequent biological effects were evaluated by an induction of apoptosis and neuron survival focusing on the dependencies of the animal strains, SCID, B6, B6C3F1, C3H, used for brain cell culture, SCID was the most sensitive and C3H the least sensitive to particle radiation as evaluated by 10% apoptotic criterion. The LET dependency was compared with using SCID and B6 cells exposing to different ions (H, C, Ne, Si, Ar, and Fe). Although no detectable LET dependency was observed in the high LET (55-200 keV/micrometers) and low dose (<0.5 Gy) regions. The survivability profiles of the neurons were different in the mouse strains and ions. In this report, a result of memory and learning function to adult mice after whole-body and brain local irradiation at carbon ion and iron ion.
Document ID
20050219169
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Nojima, Kumie
(International Space Radiation Laboratory, National Institute of Radiological Sciences (NIRS) Inage-ku, Chiba, Japan)
Nakadai, Taeko
Kohno, Yukio
Vazquez, Marcelo E.
Yasuda, Nakahiro
Nagaoka, Shunji
Date Acquired
August 23, 2013
Publication Date
November 1, 2004
Publication Information
Publication: Uchu seibutsu kagaku
Volume: 18
Issue: 3
ISSN: 0914-9201
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Radiation Health
Non-NASA Center

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