NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Activation of nuclear transcription factor-kappaB in mouse brain induced by a simulated microgravity environmentMicrogravity induces inflammatory responses and modulates immune functions that may increase oxidative stress. Exposure to a microgravity environment induces adverse neurological effects; however, there is little research exploring the etiology of these effects resulting from exposure to such an environment. It is also known that spaceflight is associated with increase in oxidative stress; however, this phenomenon has not been reproduced in land-based simulated microgravity models. In this study, an attempt has been made to show the induction of reactive oxygen species (ROS) in mice brain, using ground-based microgravity simulator. Increased ROS was observed in brain stem and frontal cortex with concomitant decrease in glutathione, on exposing mice to simulated microgravity for 7 d. Oxidative stress-induced activation of nuclear factor-kappaB was observed in all the regions of the brain. Moreover, mitogen-activated protein kinase kinase was phosphorylated equally in all regions of the brain exposed to simulated microgravity. These results suggest that exposure of brain to simulated microgravity can induce expression of certain transcription factors, and these have been earlier argued to be oxidative stress dependent.
Document ID
20050232162
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Wise, Kimberly C. (Texas Southern University Houston, Texas 77004, United States)
Manna, Sunil K.
Yamauchi, Keiko
Ramesh, Vani
Wilson, Bobby L.
Thomas, Renard L.
Sarkar, Shubhashish
Kulkarni, Anil D.
Pellis, Neil R.
Ramesh, Govindarajan T.
Date Acquired
August 23, 2013
Publication Date
March 1, 2005
Publication Information
Publication: In vitro cellular & developmental biology. Animal
Volume: 41
Issue: 4-Mar
ISSN: 1071-2690
Subject Category
Aerospace Medicine
Funding Number(s)
CONTRACT_GRANT: NCC9-165
CONTRACT_GRANT: NAG9-1414
CONTRACT_GRANT: NCC8-168
CONTRACT_GRANT: NCC1-02038
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Regulatory Physiology