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Record Details

Record 26 of 962
Multiple melanocortin receptors are expressed in bone cells
External Online Source: doi:10.1016/j.bone.2005.01.020
Author and Affiliation:
Zhong, Qing(Institute of Molecular Medicine and Genetics, Augusta, GA 30912, United States)
Sridhar, Supriya
Ruan, Ling
Ding, Ke-Hong
Xie, Ding
Insogna, Karl
Kang, Baolin
Xu, Jianrui
Bollag, Roni J.
Isales, Carlos M.
Abstract: Melanocortin receptors belong to the seven transmembrane domain, G-protein coupled family of receptors. There are five members of this receptor family labeled MC1R-MC5R. These receptors are activated by fragments derived from a larger molecule, proopiomelanocortin (POMC) and include ACTH, alpha beta and gamma-MSH and beta-endorphin. Because of in vitro and in vivo data suggesting direct effects of these POMC molecules on bone and bone turnover, we examined bone and bone derived cells for the presence of the various members of the melanocortin receptor family. We report that the five known melanocortin receptors are expressed to varying degrees in osteoblast-like and osteoclastic cells. POMC fragments increased proliferation and expression of a variety of genes in osteoblastic cells. Furthermore, POMC mRNA was detected in osteoclastic cells. These data demonstrate that POMC-derived peptide hormones acting through high affinity melanocortin receptors have specific effects on bone cells. Thus, in addition to the indirect effects of POMC-derived hormones on bone turnover through their modulation of steroid hormone secretion, POMC fragments may have direct and specific effects on bone cell subpopulations.
Publication Date: May 01, 2005
Document ID:
20050232527
(Acquired Nov 01, 2005)
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: Bone; p. 820-31; (ISSN 8756-3282); Volume 36; 5
Publisher Information: United States
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: BONES; OSTEOBLASTS; CHEMICAL BONDS; CYCLIC AMP; MICE; OLIGONUCLEOTIDES; PHYSIOCHEMISTRY; PITUITARY HORMONES; POLYMERASE CHAIN REACTION; POLYNUCLEOTIDES; PROTEINS; RATS; RIBONUCLEIC ACIDS; THYMIDINE
Other Descriptors: OSTEOBLASTS/METABOLISM; RECEPTORS, MELANOCORTIN/METABOLISM; ANIMALS; BASE SEQUENCE; BLOTTING, NORTHERN; BLOTTING, SOUTHERN; CORTICOTROPIN/METABOLISM; CYCLIC AMP/METABOLISM; DNA PRIMERS; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PRO-OPIOMELANOCORTIN/GENETICS; PROTEIN BINDING; RNA, MESSENGER/GENETICS; RATS; RECEPTORS, CORTICOTROPIN/METABOLISM; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; THYMIDINE/METABOLISM; NASA DISCIPLINE MUSCULOSKELETAL; NON-NASA CENTER
Availability Source: Other Sources
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