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protection against uv and x-ray cataracts using dynamic light scatteringStatic and dynamic light scattering (SLS and DLS) analysis was used to investigate the aggregation of lens proteins in a hyperbaric oxygen (HBO)/guinea pig in vivo model for nuclear cataract. Nuclear cataract, an opacity which occurs in the center of the lens, is a major type of human maturity-onset cataract for which the cause is not well-understood. HBO is commonly used in major hospitals for treating complications such as poor wound healing due to impaired blood circulation. It is known that treatment of human patients with HBO for extended periods of time can produce nuclear cataract. Guinea pigs, initially 18 months old, were treated with HBO (2.5 atm of 100% O2 for 2.5 hr) 3x per week for 7 months to increase tie level of lens nuclear light scattering. Age-matched animals were used for controls. The eyes of the animals were analyzed in vivo using an integrated static and DLS fiber optic probe in collaboration with the NASA group. DLS in vivo was used to measure the size of lens proteins at 50 different locations across the optical axis of the guinea pig lens.
Document ID
20050238467
Document Type
Contractor or Grantee Report
Authors
Giblin, Frank J.
(Oakland Univ. Rochester, MI, United States)
Date Acquired
August 23, 2013
Publication Date
October 31, 2005
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: NAG3-2792
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.
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