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Glucose determination in human aqueous humor with Raman spectroscopyIt has been suggested that spectroscopic analysis of the aqueous humor of the eye could be used to indirectly predict blood glucose levels in diabetics noninvasively. We have been investigating this potential using Raman spectroscopy in combination with partial least squares (PLS) analysis. We have determined that glucose at clinically relevant concentrations can be accurately predicted in human aqueous humor in vitro using a PLS model based on artificial aqueous humor. We have further determined that with proper instrument design, the light energy necessary to achieve clinically acceptable prediction of glucose does not damage the retinas of rabbits and can be delivered at powers below internationally acceptable safety limits. Herein we summarize our current results and address our strategies to improve instrument design. 2005 Society of Photo-Optical Instrumentation Engineers.
Document ID
20050240293
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Lambert, James L.
(Jet Propulsion Lab., California Inst. of Tech. Pasadena, CA United States)
Pelletier, Christine C.
Borchert, Mark
Date Acquired
August 23, 2013
Publication Date
May 1, 2005
Publication Information
Publication: Journal of biomedical optics
Volume: 10
Issue: 3
ISSN: 1083-3668
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other

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