NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Markers of bone resorption and calcium metabolism are related to dietary intake patterns in male and female bed rest subjectsDietary potassium and protein intakes predict net endogenous acid production in humans. Intracellular buffers, including exchangeable bone mineral, play a crucial role in balancing chronic acid-base perturbations in the body; subsequently, chronic acid loads can potentially contribute to bone loss. Bone is lost during space flight, and a dietary countermeasure would be desirable for many reasons. We studied the ability of diet protein and potassium to predict levels of bone resorption markers in males and females. Identical twin pairs (8 M, 7 F) were assigned to 2 groups: bed rest (sedentary, SED) or bed rest with supine treadmill exercise in a lower body negative pressure chamber (EX). Diet was controlled for 3 d before and 30 d of bed rest (BR). Urinary Ca, N-telopeptide (NTX), and pyridinium crosslinks (PYD) were measured before and on days 5, 12, 19, and 26 of BR. Data were analyzed by Pearson correlation (P<0.05). The ratio of dietary animal protein/potassium intake was not correlated with NTX before BR for males or females, but they were positively correlated in both groups of males during bed rest. Dietary animal protein/potassium and urine Ca were correlated before and during bed rest for the males, and only during bed rest for the females. Conversely, the ratio of dietary vegetable protein/potassium intake was negatively correlated with urinary calcium during bed rest for the females, but there was no relationship between vegetable protein/potassium intake and bone markers for the males. These data suggest that the ratio of animal protein/potassium intake may affect bone, particularly in bed rest subjects. These data show that the type of protein and gender may be additional factors that modulate the effect of diet on bone metabolism during bed rest. Altering this ratio may help prevent bone loss on Earth and during space flight.
Document ID
20060010414
Acquisition Source
Johnson Space Center
Document Type
Conference Paper
Authors
Smith, Scott M.
(NASA Johnson Space Center Houston, TX, United States)
Zwart, S. R.
(NASA Johnson Space Center Houston, TX, United States)
Hargens, A. r.
(NASA Johnson Space Center Houston, TX, United States)
Date Acquired
August 23, 2013
Publication Date
January 1, 2006
Subject Category
Life Sciences (General)
Meeting Information
Meeting: 15th IAA Humans in Space Conference
Location: Graz
Country: Austria
Start Date: May 22, 2004
End Date: May 26, 2004
Funding Number(s)
CONTRACT_GRANT: NAG9-1425
CONTRACT_GRANT: NIH-MO1-RR00827
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

Available Downloads

There are no available downloads for this record.
No Preview Available