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Heritability of markers of bone metabolismSeveral classic twin studies show genetic effects on markers of bone health, including bone mineral density and parathyroid hormone (PTH). This study was performed to assess the relative contribution of genetics to biochemical markers of bone metabolism. Fifteen sets of identical twins (8 male, 7 female) were housed in a clinical research center where diet was controlled (15% protein, 55% carbohydrate, 30% fat) for 3 consecutive days. Each day, 24-h urine pools were collected and N-telopeptide (NTX), deoxypyridinoline (DPD), calcium, and serum PTH were measured. The broad-sense heritability factor (H2) is an estimation of the portion of the total variance of a given phenotype that is attributable to genetic variance. H2 was estimated from the correlation coefficient of the phenotype data. H2 for NTX was 94% for males and 80% for females, DPD was 88% for males and 97% for females, urinary calcium excretion was 97% for males and 90% for females, and PTH was 92% for males and 79% for females. Since environmental variability was minimized for the 3 days of data collection, these heritability factors are likely overestimated. Nonetheless, the data support the concept that PTH is a predominantly heritable trait, and suggest that NTX, DPD, and calcium excretion are as well. These biochemical data support the previously documented heritability of bone health.
Document ID
20060010436
Acquisition Source
Johnson Space Center
Document Type
Conference Paper
Authors
Smith, Scott M.
(NASA Johnson Space Center Houston, TX, United States)
Zwart, S. R.
(NASA Johnson Space Center Houston, TX, United States)
Hargens, A. R.
(NASA Johnson Space Center Houston, TX, United States)
Date Acquired
August 23, 2013
Publication Date
January 1, 2005
Subject Category
Life Sciences (General)
Meeting Information
Meeting: Experimental Biology Meeting
Location: San Diego, CA
Country: United States
Start Date: April 1, 2005
Funding Number(s)
CONTRACT_GRANT: NIH-M01-RR00827
CONTRACT_GRANT: NAG9-1425
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

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