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WISE-2005: Integrative Cardiovascular Responses with LBNP during 60-Day Bed Rest in WomenDuring 2005, 24 women will take part in the Women International Space-simulation for Exploration (WISE). In this paper we report on the first phase that studied 4 Exercise (EX+LBNP), 4 nutrition (NUT), and 4 no countermeasure control (CON) subjects. The EX+LBNP group completed regular exercise on a treadmill inside LBNP, flywheel resistive exercise and static periods of LBNP, and had recovery days. The NUT group received daily protein supplements. Integrative cardiovascular responses were obtained and here we report data for heart rate during LBNP, blood volume and angiotensin 11. LBNP was applied at 0, -10, -20 and -30 mmHg for 2-minutes for each stage. Blood was sampled prebed rest and on HDT-60. After 60-days head down bed rest, HR in the CON group increased by 6.1+/-2.8 bpm at rest and by 20.7+/-5.0 bpm at -30 mmHg LBNP. The EX+LBNP group had increases of 3.6+/-5.6 and 11.6+/-5.4 bpm, while the NUT group HR increased 2.6+/-3.1 and 9.4+/-3.6 bpm. The EX+LBNP group had almost no change in blood volume or plasma angiotensin II from pre-bed rest to HDT60, while both the CON and NUT groups had larger increases in plasma volume and almost double concentrations of angiotensin II. These data show a positive effect in the EX+LBNP group on the heart rate response as well as an unexpected possible benefit in the NUT group. Further studies are required to confirm possible cardiovascular benefits of the protein supplement.
Document ID
20060054401
Acquisition Source
Goddard Space Flight Center
Document Type
Reprint (Version printed in journal)
Authors
Hughson, R. L.
(Waterloo Univ. Ontario, Canada)
Kerbeci, P.
(Centre Hospitalier Univ. Tours, France)
Arbeille, Ph.
(Centre Hospitalier Univ. Tours, France)
Mattar, L.
(Waterloo Univ. Ontario, Canada)
Shoemaker, J. K.
(University of Western Ontario London, Ontario, Canada)
Date Acquired
August 23, 2013
Publication Date
July 1, 2005
Publication Information
Publication: Journal of Gravitational Physiology, Volume 12, Number 1
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other

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