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Centrifugation Effects on Estrous Cycling, Mating Success and Pregnancy Outcome in RatsWe analyzed the effects of 2-g centrifugation on estrous cycling, mating success and pregnancy outcome in rats. Sexually mature female and male rats were assigned to either 2-g centrifuge or non-centrifuge conditions, and to non-breeding or breeding conditions. In non-breeding females, estrous cycles were analyzed by examining vaginal cytology before and for 35 days during centrifugation. Breeding females were time-mated following 7 days of adaptation to centrifugation. Following adaptation to centrifugation, estrous cycle duration over a five-cycle period was similar in centrifuged and non-centrifuged females. Identical numbers of centrifuged and non-centrifuged females conceived, however centrifuged females took four-times longer than controls to achieve conception. Births occurred at the normal gestational length. Pup birth weight and postnatal survival were p<0.05 reduced in centrifuged as compared to non-centrifuged groups. In conclusion, 2-g centrifugation had no effect on estrous cycle length or the probably of becoming pregnant but delayed conception and diminished pregnancy outcome.
Document ID
20060054415
Acquisition Source
Goddard Space Flight Center
Document Type
Reprint (Version printed in journal)
Authors
Ronca, April E.
(Wake Forest Univ. Winston-Salem, NC, United States)
Rushing, Linda S.
(NASA Ames Research Center Moffett Field, CA, United States)
Tou, Janet
(West Virginia Univ. Morgantown, WV, United States)
Wade, Charles E.
(Army Inst. of Surgical Research Fort Sam Houston, TX, United States)
Baer, Lisa A.
(NASA Ames Research Center Moffett Field, CA, United States)
Date Acquired
August 23, 2013
Publication Date
July 1, 2005
Publication Information
Publication: Journal of Gravitational Physiology, Volume 12, Number 1
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: NNA04CK83A
CONTRACT_GRANT: NIH-MH-46485
Distribution Limits
Public
Copyright
Other

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