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Human Adaptation Genetic Response Suites: Toward New Interventions and Countermeasures for SpaceflightGenetic response suites in human lymphocytes in response to microgravity are important to identify and further study in order to augment human physiological adaptation to novel environments. Emerging technologies, such as DNA micro array profiling, have the potential to identify novel genes that are involved in mediating adaptation to these environments. These genes may prove to be therapeutically valuable as new targets for countermeasures, or as predictive biomarkers of response to these new environments. Human lymphocytes cultured in lg and microgravity analog culture were analyzed for their differential gene expression response. Different groups of genes related to the immune response, cardiovascular system and stress response were then analyzed. Analysis of cells from multiple donors reveals a small shared set that are likely to be essential to adaptation. These three groups focus on human adaptation to new environments. The shared set contains genes related to T cell activation, immune response and stress response to analog microgravity.
Document ID
20060054417
Acquisition Source
Goddard Space Flight Center
Document Type
Reprint (Version printed in journal)
Authors
Sundaresan, A.
(Universities Space Research Association Houston, TX, United States)
Pellis, N. R.
(NASA Johnson Space Center Houston, TX, United States)
Date Acquired
August 23, 2013
Publication Date
July 1, 2005
Publication Information
Publication: Journal of Gravitational Physiology, Volume 12, Number 1
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other

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