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WIse-2005: Combined Aerobic and Resistive Exercise May Help Mitigate Bone Loss During 60-D Simulated Microgravity in WomenExercise can attenuate bone loss associated with disuse during bed rest (BR), an analog of space flight. Previous studies have examined the efficacy of aerobic or resistive exercise countermeasures, but not in combination. We sought to determine the effect of a combined resistive and aerobic exercise regimen on bone metabolism during BR. After a 20-d ambulatory adaptation to confinement and diet, 16 women participated in a 60-d head-down-tilt BR. Control subjects (CN, n=8) performed no countermeasures. Exercise subjects, (EX, n=8) participated in exercise alternating daily between supine treadmill exercise within lower body negative pressure and resistive fly-wheel exercise (6-d wk(sup -1)). In the last week of BR, bone resorption was greater (p less than 79 plus or minus 44%, mean plus or minus SD) and EX groups (64 50%). N-telopeptide also increased (CN: 51 plus or minus 34%; EX: 43 plus or minus 56%). However, bone-specific alkaline phosphatase, a bone formation marker, tended to be higher in EX (26 plus or minus 18%) than in CN (8 plus or minus 33%) groups. The combination of resistive and aerobic exercise does not prevent bone resorption, but may promote formation, potentially mitigating the net bone loss associated with simulated microgravity. This study was supported by CNES, CSA, ESA, NASA, and NASA grant NNJ04HF71G to ARH. MEDES (French Institute for Space Medicine and Physiology) organized the study.
Document ID
Document Type
Preprint (Draft being sent to journal)
Smith, Scott M.
(NASA Johnson Space Center Houston, TX, United States)
Zwart, S. R.
(Universities Space Research Association Houston, TX, United States)
Heer, M. A.
(Deutsche Forschungsanstalt fuer Luft- und Raumfahrt Germany)
Lee, S. M. C.
(Wyle Labs., Inc. Houston, TX, United States)
Macias, B. R.
(California Univ. San Diego, CA, United States)
Schneider, S. M.
(New Mexico Univ. NM, United States)
Trappe, S. M.
(Ball State Univ. Muncie, IN, United States)
Hargens, A. R.
(California Univ. San Diego, CA, United States)
Date Acquired
August 23, 2013
Publication Date
January 1, 2006
Subject Category
Aerospace Medicine
Meeting Information
Experimental Biology(Washington, DC)
Funding Number(s)
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