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Record 36 of 781
WIse-2005: Combined Aerobic and Resistive Exercise May Help Mitigate Bone Loss During 60-D Simulated Microgravity in Women
Author and Affiliation:
Smith, Scott M.(NASA Johnson Space Center, Houston, TX, United States)
Zwart, S. R.(Universities Space Research Association, Houston, TX, United States)
Heer, M. A.(Deutsche Forschungsanstalt fuer Luft- und Raumfahrt, Germany)
Lee, S. M. C.(Wyle Labs., Inc., Houston, TX, United States)
Macias, B. R.(California Univ., San Diego, CA, United States)
Schneider, S. M.(New Mexico Univ., NM, United States)
Trappe, S. M.(Ball State Univ., Muncie, IN, United States)
Hargens, A. R.(California Univ., San Diego, CA, United States)
Abstract: Exercise can attenuate bone loss associated with disuse during bed rest (BR), an analog of space flight. Previous studies have examined the efficacy of aerobic or resistive exercise countermeasures, but not in combination. We sought to determine the effect of a combined resistive and aerobic exercise regimen on bone metabolism during BR. After a 20-d ambulatory adaptation to confinement and diet, 16 women participated in a 60-d head-down-tilt BR. Control subjects (CN, n=8) performed no countermeasures. Exercise subjects, (EX, n=8) participated in exercise alternating daily between supine treadmill exercise within lower body negative pressure and resistive fly-wheel exercise (6-d wk(sup -1)). In the last week of BR, bone resorption was greater (p less than 79 plus or minus 44%, mean plus or minus SD) and EX groups (64 50%). N-telopeptide also increased (CN: 51 plus or minus 34%; EX: 43 plus or minus 56%). However, bone-specific alkaline phosphatase, a bone formation marker, tended to be higher in EX (26 plus or minus 18%) than in CN (8 plus or minus 33%) groups. The combination of resistive and aerobic exercise does not prevent bone resorption, but may promote formation, potentially mitigating the net bone loss associated with simulated microgravity. This study was supported by CNES, CSA, ESA, NASA, and NASA grant NNJ04HF71G to ARH. MEDES (French Institute for Space Medicine and Physiology) organized the study.
Publication Date: Jan 01, 2006
Document ID:
20060056238
(Acquired Dec 19, 2006)
Subject Category: AEROSPACE MEDICINE
Document Type: Preprint
Meeting Information: Experimental Biology; 28 Apr. - 2 May 2007; Washington, DC; United States
Contract/Grant/Task Num: NNJ04HF71G
Financial Sponsor: NASA Johnson Space Center; Houston, TX, United States
Organization Source: NASA Johnson Space Center; Houston, TX, United States
Description: 1p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: AEROSPACE MEDICINE; BONE DEMINERALIZATION; MICROGRAVITY; PHYSICAL EXERCISE; FEMALES; RESISTANCE; SIMULATION; HEAD DOWN TILT; LOWER BODY NEGATIVE PRESSURE; DIETS; BED REST; EUROPEAN SPACE AGENCY; METABOLISM; TREADMILLS
Availability Source: Other Sources
Availability Notes: Abstract Only
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