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Experiment "Regeneration" Performed Aboard the Russian Spacecraft Foton-M2 in 2005The experiments on the newts performed earlier aboard Russian biosate llites showed that the rate of lens and tail regeneration in space wa s greater than on the ground. In parallel it was found that the numbe r of cells in S-phase was greater in space-flown animals than in the ground controls. However, it was unclear whether cell proliferation stimulation was induced by micro-g per se. Molecular mechanisms under lying the change also remained obscure. These issues were addressed b y the joint Russian-American experiment "Regeneration" flown on Foton -M2 in 2005. The method for in-flight delivering DNA precursor BrdU was developed. The experiment showed that during the flight the numbe r of S-phase cells in the regenerating eyes and tails increased. Thes e data together with those obtained earlier suggest that cell prolife ration increases in response to the effects of both micro-g and 1-g a fter return to Earth. The expression of bFGF in regenerating tissues of "flown" newts and ground controls was examined using immuno-histo chemistry. Obtained results suggest that this growth factor is a part icipant of the promotional effect of space flight upon cell prolifera tion in lens and tail regenerates.
Document ID
20070022696
Acquisition Source
Ames Research Center
Document Type
Reprint (Version printed in journal)
Authors
Grigoryan, Elonora
(Academy of Sciences (Russia) Moscow, Russian Federation)
Almeida, Eduardo
(NASA Ames Research Center Moffett Field, CA, United States)
Domaratskaya, Elena
(Academy of Sciences (Russia) Moscow, Russian Federation)
Poplinskaya, Valentina
(Academy of Sciences (Russia) Moscow, Russian Federation)
Aleinikova, Karina
(Academy of Sciences (Russia) Moscow, Russian Federation)
Tairbekov, Murad
(Academy of Sciences (Russia) Moscow, Russian Federation)
Mitashov, Victor
(Academy of Sciences (Russia) Moscow, Russian Federation)
Date Acquired
August 23, 2013
Publication Date
July 1, 2006
Publication Information
Publication: Journal of Gravitational Physiology, Volume 13, No. 1
Subject Category
Aerospace Medicine
Funding Number(s)
CONTRACT_GRANT: RFBR-04-04-48044
CONTRACT_GRANT: RFBR-05-04-48502
Distribution Limits
Public
Copyright
Other

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