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The SMM Model as a Boundary Value Problem Using the Discrete Diffusion EquationA generalized single step stepwise mutation model (SMM) is developed that takes into account an arbitrary initial state to a certain partial difference equation. This is solved in both the approximate continuum limit and the more exact discrete form. A time evolution model is developed for Y DNA or mtDNA that takes into account the reflective boundary modeling minimum microsatellite length and the original difference equation. A comparison is made between the more widely known continuum Gaussian model and a discrete model, which is based on modified Bessel functions of the first kind. A correction is made to the SMM model for the probability that two individuals are related that takes into account a reflecting boundary modeling minimum microsatellite length. This method is generalized to take into account the general n-step model and exact solutions are found. A new model is proposed for the step distribution.
Document ID
20070035074
Acquisition Source
Langley Research Center
Document Type
Reprint (Version printed in journal)
Authors
Campbell, Joel
(NASA Langley Research Center Hampton, VA, United States)
Date Acquired
August 24, 2013
Publication Date
January 1, 2007
Subject Category
Numerical Analysis
Funding Number(s)
WBS: WBS 810031.07.03
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.
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