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Vapor Hydrogen Peroxide as Alternative to Dry Heat Microbial ReductionThe Jet Propulsion Laboratory, in conjunction with the NASA Planetary Protection Officer, has selected vapor phase hydrogen peroxide (VHP) sterilization process for continued development as a NASA approved sterilization technique for spacecraft subsystems and systems. The goal is to include this technique, with appropriate specification, in NPG8020.12C as a low temperature complementary technique to the dry heat sterilization process. A series of experiments were conducted in vacuum to determine VHP process parameters that provided significant reductions in spore viability while allowing survival of sufficient spores for statistically significant enumeration. With this knowledge of D values, sensible margins can be applied in a planetary protection specification. The outcome of this study provided an optimization of test sterilizer process conditions: VHP concentration, process duration, a process temperature range for which the worst case D value may be imposed, a process humidity range for which the worst case D value may be imposed, and robustness to selected spacecraft material substrates.
Document ID
20080022162
Acquisition Source
Jet Propulsion Laboratory
Document Type
Preprint (Draft being sent to journal)
External Source(s)
Authors
Cash, Howard A.
(STERIS Corp. Mentor, OH, United States)
Kern, Roger G.
(Jet Propulsion Lab., California Inst. of Tech. Pasadena, CA, United States)
Chung, Shirley Y.
(Jet Propulsion Lab., California Inst. of Tech. Pasadena, CA, United States)
Koukol, Robert C.
(Jet Propulsion Lab., California Inst. of Tech. Pasadena, CA, United States)
Barengoltz, Jack B.
(Jet Propulsion Lab., California Inst. of Tech. Pasadena, CA, United States)
Date Acquired
August 24, 2013
Publication Date
July 16, 2006
Subject Category
Space Sciences (General)
Meeting Information
Meeting: 36th Committee on Space Research (COSPAR) Scientific Assembly
Location: Beijing
Country: China
Start Date: July 16, 2006
End Date: July 23, 2006
Distribution Limits
Public
Copyright
Other
Keywords
vapor hydrogen peroxide
G. stearothermophilus

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