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Nutritional Status in Humans during Long-Duration Bed RestBed rest is a valuable ground-based model for many of the physiological changes associated with space flight. A series of studies was undertaken to evaluate nutritional changes during and after 60 or 90 days of -6 head-down-tilt bed rest. A total of 11 subjects (8 M, 3 F; age 26-55 y) participated in the studies. Blood and urine were collected twice before bed rest and once per month during bed rest. Samples were analyzed in batch at the end of each study. Data were analyzed using repeated-measures ANOVA. Markers of bone resorption (such as n-telopeptide excretion, p less than 0.05) increased during bed rest, and 25-OH vitamin D status tended to decline (p=0.06). During bed rest oxidative damage markers, such as superoxide dismutase increased (p less than 0.01) and 8-(OH)-2'-deoxyguanosine tended to increase (p=0.07); whereas total antioxidant capacity decreased (p less than 0.02). Iron status indices showed patterns of increased iron stores, with decreased transferrin receptors (p less than 0.001). Biochemical markers revealed a tendency toward a loss of muscle mass, by lower excretion of creatinine and 3-methyl-histidine during bed rest. All of these changes are very similar to those observed during space flight, and further document the utility of bed rest as a model of space flight.
Document ID
20080026090
Acquisition Source
Johnson Space Center
Document Type
Conference Paper
Authors
Smith, Scott M.
(NASA Johnson Space Center Houston, TX, United States)
MatthewsOliver, Susan A.
(Enterprise Advisory Services, Inc. Houston, TX, United States)
Dillon, E. Lichar
(Enterprise Advisory Services, Inc. Houston, TX, United States)
Fesperman, Vernell
(Enterprise Advisory Services, Inc. Houston, TX, United States)
Date Acquired
August 24, 2013
Publication Date
April 1, 2006
Subject Category
Aerospace Medicine
Meeting Information
Meeting: Experimental Biology
Location: San Francisco, CA
Country: United States
Start Date: April 1, 2006
End Date: April 5, 2006
Sponsors: Federation of American Societies for Experimental Biology
Distribution Limits
Public
Copyright
Other

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