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Patent Foramen Ovale in Patients with Cerebral Infarction: A Transesophageal Echocradigraphy StudyPatent foramen ovale was detected in 37 patients (32%). Mean age was similar in those with (60 years) and those without (64 years) PFO. Patent foramen ovale was more frequent among men (39%) than women (20%, P=.03). Patients with PFO had a lower frequency of atrial fibrillation, diabetes me!litus, hypertension, and peripheral vascular disease compared with those without PFO. There was no difference in frequency of the following characteristics in patients with PFO compared with those without PFO: pulmonary embolus, chronic obstructive pulmonary disease, pulmonary hypertension, peripheral embolism, prior cerebral infarction, nosocomial cerebral infarction, Valsalva maneuver at the time of cerebral infarction, recent surgery, or hemorrhagic transformation of cerebral infarction. Patent foramen ovale was found in 22 (40%) of 55 patients with infarcts of uncertain cause and in 15 (25%) of 61 with infarcts of known cause (cardioembolic, 21%; large vessel atherostenosis, 25%; lacune, 40%) (P=.08). When the analysis was restricted to patients who underwent Valsalva maneuver, PFO with right to left or bidirectional shunt was found in 19 (50%) of 38 patients with infarcts of uncertain cause and in 6 (20%) of 30 with infarcts of known cause (P=.Ol). Conclusion: Although PFO was over-represented in patients with infarcts of uncertain cause in our and other studies, it has a high frequency among patients with cerebral infarction of all types. The relation between PFO and stroke requires further study.
Document ID
20090005074
Acquisition Source
Headquarters
Document Type
Reprint (Version printed in journal)
Authors
Petty, George W.
(Mayo Clinic Rochester, MN, United States)
Khandheria, Bijoy K.
(Mayo Clinic Rochester, MN, United States)
Chu, Chu-Pin
(Mayo Clinic Rochester, MN, United States)
Sicks, JoRean D.
(Mayo Clinic Rochester, MN, United States)
Whisnant, Jack P.
(Mayo Clinic Rochester, MN, United States)
Date Acquired
August 24, 2013
Publication Date
July 1, 1997
Publication Information
Publication: (ARCH NEUROL) - Archives of Neurology
Publisher: American Medical Association
Volume: Vo 54
Issue: 7
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other

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