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Persistence of Space Radiation-Induced Cytogenetic Damage in the Blood Lymphocytes of Astronauts and the Effects of Repeat Long Duration Space MissionsThe yield of chromosome damage in astronauts blood lymphocytes has been shown to increase after long duration space missions of a few months or more. This provides a useful in vivo measurement of space radiation induced damage that takes into account individual radiosensitivity and considers the influence of microgravity and other stress conditions. We present our latest follow-up analyses of chromosome damage in astronauts blood lymphocytes assessed by fluorescence in situ hybridization (FISH) chromosome painting and collected at various times, from directly after return from space to several years after flight. For most individuals the analysis of individual time-courses for translocations revealed a temporal decline of yields with different half-lives. Dose was derived from frequencies of chromosome exchanges using preflight calibration curves, and estimates derived from samples collected a few days after return to earth lie within the range expected from physical dosimetry. However, a temporal decline in yields may indicate complications with the use of stable aberrations for retrospective dose reconstruction, and the differences in the decay time may reflect individual variability in risk from space radiation exposure. Limited data on three individuals who have participated in repeat long duration space flights indicates a lack of correlation between time in space and translocation yields, and show a possible adaptive response to space radiation exposure.
Document ID
20090014833
Document Type
Conference Paper
Authors
George, Kerry A. (Wyle Labs., Inc. Houston, TX, United States)
Cucinotta, Francis A. (NASA Johnson Space Center Houston, TX, United States)
Date Acquired
August 24, 2013
Publication Date
January 1, 2009
Subject Category
Aerospace Medicine
Report/Patent Number
JSC-18179
Meeting Information
NASA Health Investigators'' Meeting(Cologne)
Distribution Limits
Public
Copyright
Other