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Development of a GCR Event-based Risk ModelA goal at NASA is to develop event-based systems biology models of space radiation risks that will replace the current dose-based empirical models. Complex and varied biochemical signaling processes transmit the initial DNA and oxidative damage from space radiation into cellular and tissue responses. Mis-repaired damage or aberrant signals can lead to genomic instability, persistent oxidative stress or inflammation, which are causative of cancer and CNS risks. Protective signaling through adaptive responses or cell repopulation is also possible. We are developing a computational simulation approach to galactic cosmic ray (GCR) effects that is based on biological events rather than average quantities such as dose, fluence, or dose equivalent. The goal of the GCR Event-based Risk Model (GERMcode) is to provide a simulation tool to describe and integrate physical and biological events into stochastic models of space radiation risks. We used the quantum multiple scattering model of heavy ion fragmentation (QMSFRG) and well known energy loss processes to develop a stochastic Monte-Carlo based model of GCR transport in spacecraft shielding and tissue. We validated the accuracy of the model by comparing to physical data from the NASA Space Radiation Laboratory (NSRL). Our simulation approach allows us to time-tag each GCR proton or heavy ion interaction in tissue including correlated secondary ions often of high multiplicity. Conventional space radiation risk assessment employs average quantities, and assumes linearity and additivity of responses over the complete range of GCR charge and energies. To investigate possible deviations from these assumptions, we studied several biological response pathway models of varying induction and relaxation times including the ATM, TGF -Smad, and WNT signaling pathways. We then considered small volumes of interacting cells and the time-dependent biophysical events that the GCR would produce within these tissue volumes to estimate how GCR event rates mapped to biological signaling induction and relaxation times. We considered several hypotheses related to signaling and cancer risk, and then performed simulations for conditions where aberrant or adaptive signaling would occur on long-duration space mission. Our results do not support the conventional assumptions of dose, linearity and additivity. A discussion on how event-based systems biology models, which focus on biological signaling as the mechanism to propagate damage or adaptation, can be further developed for cancer and CNS space radiation risk projections is given.
Document ID
20090016156
Acquisition Source
Johnson Space Center
Document Type
Other
Authors
Cucinotta, Francis A.
(NASA Johnson Space Center Houston, TX, United States)
Ponomarev, Artem L.
(Universities Space Research Association Houston, TX, United States)
Plante, Ianik
(Universities Space Research Association Houston, TX, United States)
Carra, Claudio
(Universities Space Research Association Houston, TX, United States)
Kim, Myung-Hee
(Universities Space Research Association Houston, TX, United States)
Date Acquired
August 24, 2013
Publication Date
January 1, 2009
Subject Category
Aerospace Medicine
Report/Patent Number
JSC-18176
Meeting Information
Meeting: Heavy Ions in Therapy and Space Symposium 2009
Location: Cologne
Country: Germany
Start Date: June 6, 2009
End Date: June 10, 2009
Sponsors: Deutsche Forschungsanstalt fuer Luft- und Raumfahrt
Distribution Limits
Public
Copyright
Other

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