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Stability of Pharmaceuticals in SpaceStability testing is a tool used to access shelf life and effects of storage conditions for pharmaceutical formulations. Early research from the International Space Station (ISS) revealed that some medications may have degraded while in space. This potential loss of medication efficacy would be very dangerous to Crew health. The aim of this research project, Stability of Pharmacotherapeutic Compounds, is to study how the stability of pharmaceutical compounds is affected by environmental conditions in space. Four identical pharmaceutical payload kits containing medications in different dosage forms (liquid for injection, tablet, capsule, ointment and suppository) were transported to the ISS aboard a Space Shuttle. One of the four kits was stored on that Shuttle and the other three were stored on the ISS for return to Earth at various time intervals aboard a pre-designated Shuttle flight. The Pharmacotherapeutics laboratory used stability test as defined by the United States Pharmacopeia (USP), to access the degree of degradation to the Payload kit medications that may have occurred during space flight. Once these medications returned, the results of stability test performed on them were compared to those from the matching ground controls stored on Earth. Analyses of the results obtained from physical and chemical stability assessments on these payload medications will provide researchers additional tools to promote safe and efficacious medications for space exploration.
Document ID
20090029952
Document Type
Conference Paper
Authors
Nguyen, Y-Uyen (NASA Johnson Space Center Houston, TX, United States)
Date Acquired
August 24, 2013
Publication Date
August 13, 2009
Subject Category
Aerospace Medicine
Report/Patent Number
JSC-CN-18668
Meeting Information
SK Student Presentations
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.