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Space Radiation Heart Disease Risk Estimates for Lunar and Mars MissionsThe NASA Space Radiation Program performs research on the risks of late effects from space radiation for cancer, neurological disorders, cataracts, and heart disease. For mortality risks, an aggregate over all risks should be considered as well as projection of the life loss per radiation induced death. We report on a triple detriment life-table approach to combine cancer and heart disease risks. Epidemiology results show extensive heterogeneity between populations for distinct components of the overall heart disease risks including hypertension, ischaemic heart disease, stroke, and cerebrovascular diseases. We report on an update to our previous heart disease estimates for Heart disease (ICD9 390-429) and Stroke (ICD9 430-438), and other sub-groups using recent meta-analysis results for various exposed radiation cohorts to low LET radiation. Results for multiplicative and additive risk transfer models are considered using baseline rates for US males and female. Uncertainty analysis indicated heart mortality risks as low as zero, assuming a threshold dose for deterministic effects, and projections approaching one-third of the overall cancer risk. Medan life-loss per death estimates were significantly less than that of solid cancer and leukemias. Critical research questions to improve risks estimates for heart disease are distinctions in mechanisms at high doses (>2 Gy) and low to moderate doses (<2 Gy), and data and basic understanding of radiation doserate and quality effects, and individual sensitivity.
Document ID
20100003128
Document Type
Conference Paper
Authors
Cucinotta, Francis A. (NASA Johnson Space Center Houston, TX, United States)
Chappell, Lori (Universities Space Research Association Houston, TX, United States)
Kim, Myung-Hee (Universities Space Research Association Houston, TX, United States)
Date Acquired
August 25, 2013
Publication Date
February 3, 2010
Subject Category
Aerospace Medicine
Report/Patent Number
JSC-CN-19467
Meeting Information
NASA Human Research Program Investigators Workshop(Houston, TX)
Distribution Limits
Public
Copyright
Other