NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
space radiation induced cytogenetic damage in the blood lymphocytes of astronauts: persistence of damage after flight and the effects of repeat long duration missionsCytogenetic damage was assessed in blood lymphocytes from astronauts before and after they participated in long-duration space missions of three months or more. The frequency of chromosome damage was measured by fluorescence in situ hybridization (FISH) chromosome painting before flight and at various intervals from a few days to many months after return from the mission. For all individuals, the frequency of chromosome exchanges measured within a month of return from space was higher than their prefight yield. However, some individuals showed a temporal decline in chromosome damage with time after flight. Statistical analysis using combined data for all astronauts indicated a significant overall decreasing trend in total chromosome exchanges with time after flight, although this trend was not seen for all astronauts and the yield of chromosome damage in some individuals actually increased with time after flight. The decreasing trend in total exchanges was slightly more significant when statistical analysis was restricted to data collected more than 220 days after return from flight. In addition, limited data on multiple flights show a lack of correlation between time in space and translocation yields. Data from three crewmembers who has participated in two separate long-duration space missions provide limited information on the effect of repeat flights and show a possible adaptive response to space radiation exposure.
Document ID
20100014342
Document Type
Conference Paper
Authors
George, Kerry
(Wyle Labs., Inc. Houston, TX, United States)
Rhone, Jordan
(University Space Research Association Houston, TX, United States)
Chappell, L. J.
(University Space Research Association Houston, TX, United States)
Cucinotta, F. A.
(NASA Johnson Space Center Houston, TX, United States)
Date Acquired
August 24, 2013
Publication Date
January 1, 2010
Subject Category
Life Sciences (General)
Report/Patent Number
JSC-CN-20229
Distribution Limits
Public
Copyright
Other