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Placental Induced Growth Factor (PIGf) in Coronary Artery DiseaseOur previous studies on normal human lymphocytes have shown a five-fold increase (p less than 0.001) in angiogenic inducers such as Placental Induced Growth Factor (PIGf) in physiologically stressful environments such as modeled microgravity, a space analog. This suggests de-regulation of cardiovascular signalling pathways indicated by upregulation of PIGf. In the current study, we measured PIGf in the plasma of 33 patients with and without coronary artery disease (CAD) to investigate whether such disease is associated with increased levels of PIGf. A control consisting of 31 sex matched apparently healthy subjects was also included in the study. We observed that the levels of PIGf in CAD patients were significantly increased compared to those in healthy control subjects (p less than 0.001) and usually increased beyond the clinical threshold level (greater than 27ng/L). The mechanisms leading to up-regulation of angiogenic factors and the adaptation of organisms to stressful environments such as isolation, high altitude, hypoxia, ischemia, microgravity, increased radiation, etc are presently unknown and require further investigation in spaceflight and these other physiologically stressed environments.
Document ID
20100022569
Document Type
Conference Paper
Authors
Sundaresan, Alamelu (Texas Southern Univ. Houston, TX, United States)
Carabello, Blaise (Veteran Health Administration Houston, TX, United States)
Mehta, Satish (Enterprise Advisory Services, Inc. Houston, TX, United States)
Schlegel, Todd (NASA Johnson Space Center Houston, TX, United States)
Pellis, Neal (NASA Johnson Space Center Houston, TX, United States)
Ott, Mark (NASA Johnson Space Center Houston, TX, United States)
Pierson, Duane (NASA Johnson Space Center Houston, TX, United States)
Date Acquired
August 24, 2013
Publication Date
January 1, 2010
Subject Category
Life Sciences (General)
Report/Patent Number
JSC-CN-20826
Meeting Information
58th International Congress of Aviation and Space Medicine
Distribution Limits
Public
Copyright
Other