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A New View of Radiation-Induced Cancer: Integrating Short-and Long-Term Processes. Part I: ApproachMathematical models of radiation carcinogenesis are important for understanding mechanisms and for interpreting or extrapolating risk. There are two classes of such models: (1) long-term formalisms that track premalignant cell numbers throughout an entire lifetime but treat initial radiation dose-response simplistically and (2) short-term formalisms that provide a detailed initial dose-response even for complicated radiation protocols, but address its modulation during the subsequent cancer latency period only indirectly. We argue that integrating short- and long-term models is needed. As an example of this novel approach, we integrate a stochastic short-term initiation/ inactivation/repopulation model with a deterministic two-stage long-term model. Within this new formalism, the following assumptions are implemented: radiation initiates, promotes, or kills pre-malignant cells; a pre-malignant cell generates a clone, which, if it survives, quickly reaches a size limitation; the clone subsequently grows more slowly and can eventually generate a malignant cell; the carcinogenic potential of pre-malignant cells decreases with age.
Document ID
20100038364
Acquisition Source
Johnson Space Center
Document Type
Reprint (Version printed in journal)
Authors
Shuryak, Igor
(Columbia Univ. New York, NY, United States)
Hahnfeldt, Philip
(Tufts Univ. Boston, MA, United States)
Hlatky, Lynn
(Tufts Univ. Boston, MA, United States)
Sachs, Rainer K.
(California Univ. Berkeley, CA, United States)
Brenner, David J.
(Columbia Univ. New York, NY, United States)
Date Acquired
August 25, 2013
Publication Date
January 1, 2009
Publication Information
Publication: Radiation and Environmental Biophysics
Publisher: SpringerLink
Volume: 48
Issue: 3
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: NNJ06HA27G
Distribution Limits
Public
Copyright
Other

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