NASA Logo, External Link
Facebook icon, External Link to NASA STI page on Facebook Twitter icon, External Link to NASA STI on Twitter YouTube icon, External Link to NASA STI Channel on YouTube RSS icon, External Link to New NASA STI RSS Feed AddThis share icon
 

Record Details

Record 1 of 1039
Biological Dosimetry in Astronauts
Author and Affiliation:
George, Kerry(Wyle Integrated Science and Engineering Group, Houston, TX, United States)
Cucinotta, Francis A.(NASA Johnson Space Center, Houston, TX, United States)
Abstract: Biodosimetry data provides a direct measurement of space radiation damage, which takes into account individual radiosensitivity in the presence of confounding factors such as microgravity and other stress conditions. In contrast to physical measurements, which are external to body and require multiple devices to detect all radiation types all of which have poor sensitivity to neutrons, biodosimetry is internal and includes the effects of shielding provided by the body itself plus chromosome damage shows excellent sensitivity to protons, heavy ions, and neutrons. Moreover, chromosome damage maybe reflective of cancer risk and biodosimetry values can therefore be used to validate and develop risk assessment models that can be used to characterize excess health risk incurred by crewmembers. Cytogenetic biodosimetry methods have been used extensively for assessing terrestrial radiation exposures, and remain the most sensitive in vivo indicator of dose available to date. The main cellular radiation target is the DNA, and radiation-induced damage in the DNA molecule can be visualized as aberrations in the chromosomes (breaks in the chromosomes or exchanges of DNA material between different chromosomes). Normal chromosomes contain a single condensed and constricted area called a centromere that helps the chromosome number to remain stable when a cell divides.
Publication Date: Jan 01, 2007
Document ID:
20110008556
(Acquired Apr 11, 2011)
Subject Category: AEROSPACE MEDICINE
Report/Patent Number: JSC-CN-23294
Coverage: Final Report
Document Type: Technical Report
Financial Sponsor: NASA Johnson Space Center; Houston, TX, United States
Organization Source: NASA Johnson Space Center; Houston, TX, United States
Description: 5p; In English; Original contains color and black and white illustrations
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: CHROMOSOMES; DEOXYRIBONUCLEIC ACID; ASTRONAUTS; EXTRATERRESTRIAL RADIATION; IN VIVO METHODS AND TESTS; RADIATION DAMAGE; RADIATION MEASUREMENT; RISK ASSESSMENT; TERRESTRIAL RADIATION; CANCER; DOSIMETERS; HEALTH; MICROGRAVITY; PROTONS; SHIELDING; TARGETS; NEUTRONS; HEAVY IONS
Availability Source: Other Sources
› Back to Top
Find Similar Records
NASA Logo, External Link
NASA Official: Gerald Steeman
Site Curator: STI Program
Last Modified: August 24, 2011
Contact Us