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Conformational Structure of Tyrosine, Tyrosyl-Glycine, and Tyrosyl-Glycyl-Glycine by Double Resonance SpectroscopyWe investigated the variation in conformation for the amino acid tyrosine (Y), alone and in the small peptides tyrosine-glycine (YC) and tyrosine-glycine-glycine (YGG), in the gas phase by using UV-UV and IR-UV double resonance spectroscopy and density functional theory calculations. For tyrosine we found seven different conformations, for YG we found four different conformations, and for YGG we found three different conformations. As the peptides get larger, we observe fewer stable conformers, despite the increasing complexity and number of degrees of freedom. We find structural trends similar to those in phenylalanine-glycine glycine (FGG) and tryptophan-glycine-glycine (WGG)j however) the effect of dispersive forces in FGG for stabilizing a folded structure is replaced by that of hydrogen bonding in YGG.
Document ID
20120010504
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Abo-Riziq, Ali (California Univ. Santa Barbara, CA, United States)
Grace, Louis (California Univ. Santa Barbara, CA, United States)
Crews, Bridgit (California Univ. Santa Barbara, CA, United States)
Callahan, Michael P, (NASA Goddard Space Flight Center Greenbelt, MD, United States)
van Mourik, Tanja (Saint Andrew's Univ. United Kingdom)
de Vries, Mattanjah S, (California Univ. Santa Barbara, CA, United States)
Date Acquired
August 26, 2013
Publication Date
March 17, 2011
Publication Information
Publication: Journal of Physical Chemistry
Volume: 115
Subject Category
Inorganic, Organic and Physical Chemistry
Report/Patent Number
GSFC.JA.00383.2012
Funding Number(s)
CONTRACT_GRANT: NSF CHE-0911564
Distribution Limits
Public
Copyright
Other