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Space Radiation Cancer Risk Projections and Uncertainties - 2010Uncertainties in estimating health risks from galactic cosmic rays greatly limit space mission lengths and potential risk mitigation evaluations. NASA limits astronaut exposures to a 3% risk of exposure-induced death and protects against uncertainties using an assessment of 95% confidence intervals in the projection model. Revisions to this model for lifetime cancer risks from space radiation and new estimates of model uncertainties are described here. We review models of space environments and transport code predictions of organ exposures, and characterize uncertainties in these descriptions. We summarize recent analysis of low linear energy transfer radio-epidemiology data, including revision to Japanese A-bomb survivor dosimetry, longer follow-up of exposed cohorts, and reassessments of dose and dose-rate reduction effectiveness factors. We compare these projections and uncertainties with earlier estimates. Current understanding of radiation quality effects and recent data on factors of relative biological effectiveness and particle track structure are reviewed. Recent radiobiology experiment results provide new information on solid cancer and leukemia risks from heavy ions. We also consider deviations from the paradigm of linearity at low doses of heavy ions motivated by non-targeted effects models. New findings and knowledge are used to revise the NASA risk projection model for space radiation cancer risks.
Document ID
20130001648
Document Type
Technical Publication (TP)
Authors
Cucinotta, Francis A. (NASA Johnson Space Center Houston, TX, United States)
Kim, Myung-Hee Y. (Universities Space Research Association Houston, TX, United States)
Chappell, Lori J. (Universities Space Research Association Houston, TX, United States)
Date Acquired
August 27, 2013
Publication Date
July 1, 2011
Subject Category
Aerospace Medicine
Report/Patent Number
S-1102
JSC-CN-22961
NASA/TP-2011-216155
Distribution Limits
Public
Copyright
Public Use Permitted.

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