Non-Targeted Effects and LET: Considerations for Earth and Space Research

It is evident from reports in the literature that there are many confounding factors that are capable of modulating radiation-induced non-targeted responses such as the bystander effect and the adaptive response. It has even been suggested that the observation of non-targeted responses may not be universally observable for differing radiation qualities. Dr. William Morgan made many contributions to the study of radiation induced non-targeted effects and it is indeed this area of research where we first began our collaboration more than a decade ago. In this presentation, I will discuss elements of this journey together with a particular emphasis on the role of LET in non-targeted effects.