NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Quantitative Validation of the Integrated Medical Model (IMM) for ISS MissionsLifetime Surveillance of Astronaut Health (LSAH) provided observed medical event data on 33 ISS and 111 STS person-missions for use in further improving and validating the Integrated Medical Model (IMM). Using only the crew characteristics from these observed missions, the newest development version, IMM v4.0, will simulate these missions to predict medical events and outcomes. Comparing IMM predictions to the actual observed medical event counts will provide external validation and identify areas of possible improvement. In an effort to improve the power of detecting differences in this validation study, the total over each program ISS and STS will serve as the main quantitative comparison objective, specifically the following parameters: total medical events (TME), probability of loss of crew life (LOCL), and probability of evacuation (EVAC). Scatter plots of observed versus median predicted TMEs (with error bars reflecting the simulation intervals) will graphically display comparisons while linear regression will serve as the statistical test of agreement. Two scatter plots will be analyzed 1) where each point reflects a mission and 2) where each point reflects a condition-specific total number of occurrences. The coefficient of determination (R2) resulting from a linear regression with no intercept bias (intercept fixed at zero) will serve as an overall metric of agreement between IMM and the real world system (RWS). In an effort to identify as many possible discrepancies as possible for further inspection, the -level for all statistical tests comparing IMM predictions to observed data will be set to 0.1. This less stringent criterion, along with the multiple testing being conducted, should detect all perceived differences including many false positive signals resulting from random variation. The results of these analyses will reveal areas of the model requiring adjustment to improve overall IMM output, which will thereby provide better decision support for mission critical applications.
Document ID
20170009561
Acquisition Source
Glenn Research Center
Document Type
Presentation
Authors
Young, Millennia
(Wyle Integrated Science and Engineering Group Houston, TX, United States)
Arellano, J.
(Wyle Integrated Science and Engineering Group Houston, TX, United States)
Boley, L.
(Wyle Integrated Science and Engineering Group Houston, TX, United States)
Garcia, Y.
(Wyle Labs., Inc. Houston, TX, United States)
Saile, L.
(Wyle Labs., Inc. Houston, TX, United States)
Walton, M.
(Wyle Labs., Inc. Houston, TX, United States)
Kerstman, E.
(Wyle Labs., Inc. Houston, TX, United States)
Reyes, D.
(Wyle Labs., Inc. Houston, TX, United States)
Goodenow, D. A.
(NASA Glenn Research Center Cleveland, OH, United States)
Myers, J. G.
(NASA Glenn Research Center Cleveland, OH, United States)
Date Acquired
October 5, 2017
Publication Date
February 8, 2016
Subject Category
Aerospace Medicine
Report/Patent Number
GRC-E-DAA-TN29728
Meeting Information
Meeting: 2016 NASA Human Research Program Investigators'' Workshop
Location: Galveston, TX
Country: United States
Start Date: December 8, 2016
End Date: December 11, 2016
Sponsors: NASA Johnson Space Center
Funding Number(s)
CONTRACT_GRANT: NNJ15HK11B
WBS: WBS 444543.01.02.10
CONTRACT_GRANT: NAS9-02078
Distribution Limits
Public
Copyright
Public Use Permitted.
Keywords
validation
medical equipment
risk assessment
No Preview Available