Simulated Space Radiation and Weightlessness: Vascular-Bone Coupling Mechanisms to Preserve Skeletal HealthWe examined experimentally the effects of radiation and/or simulated weightlessness by hindlimb unloading on bone and blood vessel function either after a short period or at a later time after transient exposures in adult male, C57Bl6J mice. In sum, recent findings from our studies show that in the short term, ionizing radiation and simulate weightlessness cause greater deficits in blood vessels when combined compared to either challenge alone. In the long term, heavy ion radiation, but not unloading, can lead to persistent, adverse consequences for bone and vessel function, possibly due to oxidative stress-related pathways.
Document ID
20170009798
Acquisition Source
Ames Research Center
Document Type
Presentation
Authors
Globus, R. K. (NASA Ames Research Center Moffett Field, CA, United States)
Alwood, J. (NASA Ames Research Center Moffett Field, CA, United States)
Tahimic, C. (Wyle Labs., Inc. Moffett Field, CA, United States)
Schreurs, A.-S. (Universities Space Research Association Moffett Field, CA, United States)
Shirazi-Fard, Y. (Wyle Labs., Inc. Moffett Field, CA, United States)
Terada, M. (Universities Space Research Association Moffett Field, CA, United States)
Zaragoza, J. (New York Univ. New York, NY, United States)
Truong, T. (New York Univ. New York, NY, United States)
Bruns, K. (New York Univ. New York, NY, United States)
Castillo, A. (New York Univ. New York, NY, United States)
Limoli, C. (California Univ. Irvine, CA, United States)
Delp, M. (Florida State Univ. Gainesville, FL, United States)
Date Acquired
October 11, 2017
Publication Date
January 22, 2018
Subject Category
Life Sciences (General)Aerospace Medicine
Report/Patent Number
ARC-E-DAA-TN38900
Meeting Information
Meeting: NASA Human Research Program Investigators'' Workshop (HRP IWS 2018)