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Characterizing the Effects of Chronic 2G Centrifugation on the Rat Skeletal System
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Author and Affiliation:
Johnson, Aimee(Colorado Univ., Denver, CO, United States)
Scott, Ryan(NASA Ames Research Center, Moffett Field, CA, United States)
Ronca, April E.(NASA Ames Research Center, Moffett Field, CA, United States)
Hoban-Higgins, Tana M.(California Univ., Davis, CA, United States)
Fuller, Charles A.(California Univ., Davis, CA, United States)
Alwood, Joshua S.(NASA Ames Research Center, Moffett Field, CA, United States)
Abstract: During weightlessness, the skeletal system of astronauts is negatively affected by decreased calcium absorption and bone mass loss. Therefore, it is necessary to counteract these changes for long-term skeletal health during space flights. Our long-term plan is to assess artificial gravity (AG) as a possible solution to mitigate these changes. In this study, we aim to determine the skeletal acclimation to chronic centrifugation. We hypothesize that a 2G hypergravity environment causes an anabolic response in growing male rats. Specifically, we predict chronic 2G to increase tissue mineral density, bone volume fraction of the cancellous tissue and to increase overall bone strength. Systemically, we predict that bone formation markers (i.e., osteocalcin) are elevated and resorption markers (i.e., tartrate resistant acid phosphatase) are decreased or unchanged from controls. The experiment has three groups, each with an n8: chronic 2g, cage control (housed on the centrifuge, but not spun), and a vivarium control (normal rat caging). Pre-pubescent, male Long-Evans rats were used to assess our hypothesis. This group was subject to 90 days of 2G via centrifugation performed at the Chronic Acceleration Research Unit (CARU) at University of California Davis. After 90 days, animals were euthanized and tissues collected. Blood was drawn via cardiac puncture and the right leg collected for structural (via microcomputed tomography) and strength quantification. Understanding how counteract these skeletal changes will have major impacts for both the space-faring astronauts and the people living on Earth.
Publication Date: Oct 25, 2017
Document ID:
20170011058
(Acquired Nov 19, 2017)
Subject Category: LIFE SCIENCES (GENERAL)
Report/Patent Number: ARC-E-DAA-TN43808
Document Type: Oral/Visual Presentation
Meeting Information: Annual Meeting of the American Society for Gravitational and Space Research (ASGSR); 33rd; 25-28 Oct. 2017; Seattle, WA; United States
Meeting Sponsor: American Society for Gravitational and Space Research; Bristow, VA, United States
Contract/Grant/Task Num: NNX16AB67G
Financial Sponsor: NASA Ames Research Center; Moffett Field, CA, United States
Organization Source: NASA Ames Research Center; Moffett Field, CA, United States
Description: 1p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright; Public use permitted
NASA Terms: BONE MINERAL CONTENT; BONES; CENTRIFUGING; MUSCULOSKELETAL SYSTEM; MICROGRAVITY; HIGH GRAVITY ENVIRONMENTS; OSTEOCALCIN; BIOMARKERS; RATS; MALES; SPACE FLIGHT
Other Descriptors: GRAVITY; SKELETON; RAT
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Last Modified: November 19, 2017
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