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Group Housing During Hindlimb Unloading to Simulate Weightlessness
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Author and Affiliation:
Tahimic, Candice(Wyle Labs., Inc., Moffett Field, CA, United States)
Lowe, Moniece(Blue Marble Institute of Science, Seattle, WA, United States)
Steczina, Sonette(Blue Marble Institute of Science, Seattle, WA, United States)
Torres, Samantha(Blue Marble Institute of Science, Seattle, WA, United States)
Terada, Masahiro(Japan Aerospace Exploration Agency, Tokyo, Japan)
Schreurs, Ann-Sofie(Universities Space Research Association, Moffett Field, CA, United States)
Ronca, April(NASA Ames Research Center, Moffett Field, CA, United States)
Alwood, Joshua(NASA Ames Research Center, Moffett Field, CA, United States)
Globus, Ruth K.(NASA Ames Research Center, Moffett Field, CA, United States)
Abstract: The rodent hindlimb unloading (HU) model was developed in the 1980s to faciliate the study of mechanisms, responses, and treatments for the adverse effects of spaceflight. A number of variations on unloading systems and cage designs have been developed, although most entail individually housing the HU animals. In this study, we performed hindlimb unloading under group housing conditions. Our preliminary results indicate that HU animals that were group housed for 30 days, displayed musculoskeletal decrements associated with disuse, and further, body weights did not differ compared to age-matched controls. In conclusion, group housing of HU mice provides a novel means to simulate weightlessness under conditions that more closely resemble living conditions of Rodent Research Project ISS flight hardware habitats, and minimizes the social stress of isolation, which is consistent with current animal welfare standards (Guide for the Care and Use of Laboratory Animals: Eighth Edition, National Research Council).
Publication Date: Oct 25, 2017
Document ID:
20170011548
(Acquired Dec 13, 2017)
Subject Category: AEROSPACE MEDICINE
Report/Patent Number: ARC-E-DAA-TN48019
Document Type: Conference Paper
Meeting Information: The American Society for Gravitational and Space Research (ASGSR); 25-28 Oct. 2017; Seattle, WA; United States
Meeting Sponsor: American Society for Gravitational and Space Research; Bristow, VA, United States
Contract/Grant/Task Num: NNA14AB82C; NNA16BD14C; NNX15AG98A
Financial Sponsor: NASA Ames Research Center; Moffett Field, CA, United States
Organization Source: NASA Ames Research Center; Moffett Field, CA, United States
Description: 16p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright; Public use permitted
NASA Terms: HINDLIMB SUSPENSION; MICE; WEIGHTLESSNESS; SIMULATION; MUSCULOSKELETAL SYSTEM; HOUSINGS; GROUP DYNAMICS; SOCIAL ISOLATION; CLASSES; BODY WEIGHT; FOOD INTAKE
Other Descriptors: HINDLIMB UNLOADING; GROUP HOUSING; BON
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