NASA Logo, External Link
Facebook icon, External Link to NASA STI page on Facebook Twitter icon, External Link to NASA STI on Twitter YouTube icon, External Link to NASA STI Channel on YouTube RSS icon, External Link to New NASA STI RSS Feed AddThis share icon
 

Record Details

Record 1 of 1
Compositions and Methods for Inhibiting Gene Expressions
NTRS Full-Text: Click to View  [PDF Size: 1.4 MB]
Author and Affiliation:
Williams, Loren D. [Inventor]
Fang, Po-Yu [Inventor]
Hsiao, Chiaolong [Inventor]
Williams, Justin [Inventor]
Abstract: A combined packing and assembly method that efficiently packs ribonucleic acid (RNA) into virus like particles (VLPs) has been developed. The VLPs can spontaneously assemble and load RNA in vivo, efficiently packaging specifically designed RNAs at high densities and with high purity. In some embodiments the RNA is capable of interference activity, or is a precursor of a RNA capable of causing interference activity. Compositions and methods for the efficient expression, production and purification of VLP-RNAs are provided. VLP-RNAs can be used for the storage of RNA for long periods, and provide the ability to deliver RNA in stable form that is readily taken up by cells.
Publication Date: Apr 03, 2018
Document ID:
20180002674
(Acquired May 16, 2018)
Subject Category: LIFE SCIENCES (GENERAL)
Report/Patent Number: US-Patent-9,932,563, US-Patent-Appl-SN-14/911,645
Document Type: Patent
Contract/Grant/Task Num: NNA09DA78A
Financial Sponsor: NASA Ames Research Center; Moffett Field, CA, United States
Organization Source: Georgia Tech Research Corp.; Atlanta, GA, United States
Description: 19p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: No Copyright; Work of the U.S. Government - Public use permitted
NASA Terms: RIBONUCLEIC ACIDS; IN VIVO METHODS AND TESTS; PACKAGING; VIRUSES; PURIFICATION; ASSEMBLING; GENE EXPRESSION; PATENTS; INVENTIONS
Miscellaneous Notes: This application is a 371 application of International Application No. PCT/2014/055149, filed Sep. 11, 2014, which claims priority to and benefit of U.S. Provisional Patent Application No. 61/876,450 filed on Sep. 11, 2013.
› Back to Top
Find Similar Records
NASA Logo, External Link
NASA Official: Gerald Steeman
Site Curator: STI Program
Last Modified: May 16, 2018
Contact Us