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Response of mouse epidermal cells to single doses of heavy-particlesThe survival of mouse epidermal cells to heavy-particles has been studied In Vivo by the Withers clone technique. Experiments with accelerated helium, lithium and carbon ions were performed. The survival curve for the helium ion irradiations used a modified Bragg curve method with a maximum tissue penetration of 465 microns, and indicated that the dose needed to reduce the original cell number to 1 surviving cell/square centimeters was 1525 rads with a D sub o of 95 rads. The LET at the basal cell layer was 28.6 keV per micron. Preliminary experiments with lithium and carbon used treatment doses of 1250 rads with LET's at the surface of the skin of 56 and 193 keV per micron respectively. Penetration depths in skin were 350 and 530 microns for the carbon and lithium ions whose Bragg curves were unmodified. Results indicate a maximum RBE for skin of about 2 using the skin cloning technique. An attempt has been made to relate the epidermal cell survival curve to mortality of the whole animal for helium ions.
Document ID
19720010038
Document Type
Conference Paper
Authors
Leith, J. T. (California Univ. Berkeley. Lawrence Radiation Lab, CA, United States)
Schilling, W. A. (California Univ. Berkeley. Lawrence Radiation Lab, CA, United States)
Welch, G. P. (California Univ. Berkeley. Lawrence Radiation Lab, CA, United States)
Date Acquired
August 6, 2013
Publication Date
January 1, 1972
Publication Information
Publication: NASA, Washington Proc. of the Natl. Symp. on Nat. and Manmade Radiation in Space
Subject Category
BIOSCIENCES
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

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IDRelationTitle19720009951Analytic PrimaryProceedings of the National Symposium on Natural and Manmade Radiation in Space