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Cross-Cutting Computational Modeling Project: Integrative Modeling ApproachA wide range of computational models and analyses have been applied to spaceflight risk assessment and countermeasure development. The benefits of using computational modeling to enhance Human Research Program (HRP) goals include the ability to mathematically represent physiological systems, integrate multiple, discrete experimental measures, span multiple temporal and spatial scales, determine important factors within the system and provide estimates of unmeasurable quantities. In the area of application, computational models provide a means of developing simulations to test hypotheses, determining key factors of the system to aid experimental design and bridging gaps in sparse data by mathematically simulating large populations. Specifically, computational models and their supporting analysis tools have the proven potential to integrate analyses of risk factors to enhance mission planning and preparation capabilities and to inform spacecraft design and countermeasure development. Appropriately applied, computational models may allow intelligent, unbiased physiological parameter assessment to enable hypothesis testing and model based design of experiments. HRP recently formed the Computational Modeling Project (CMP), managed out of Glenn Research Center, as a cross-cutting activity aimed at leveraging the growing power and acceptance of computational modeling in informing clinical, physiological, and biological studies. This presentation will provide an overview of the challenges and opportunities in implementing various forms of computational models in support of the HRPs path to risk reduction.
Document ID
Document Type
Lewandowski, B.
(NASA Glenn Research Center Cleveland, OH, United States)
Nelson, E. S.
(NASA Glenn Research Center Cleveland, OH, United States)
Myers, J. G.
(NASA Glenn Research Center Cleveland, OH, United States)
Gilkey, K.
(NASA Glenn Research Center Cleveland, OH, United States)
Date Acquired
August 27, 2018
Publication Date
January 22, 2018
Subject Category
Computer Programming And Software
Aerospace Medicine
Report/Patent Number
Meeting Information
Meeting: 2018 NASA Human Research Program Investigators'' Workshop (HRP IWS 2018)
Location: Galveston, TX
Country: United States
Start Date: January 22, 2018
End Date: January 25, 2018
Sponsors: NASA Johnson Space Center
Funding Number(s)
WBS: WBS 516724.01.02.10
Distribution Limits
Work of the US Gov. Public Use Permitted.
physiological response
gravitational physiology
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